Perioperative Care; Fluid and Electrolyte

Sometimes, however, the mechanisms fail. When they do, cells may not get everything they need, or toxic wastes may accumulate in the body. If homeostasis is not restored, the imbalance may lead to disease or even death.

What factors affect homeostasis?

Three factors that influence homeostasis are discussed: fluids and electrolytes, energy and nutrition, and immune response mediators. Cell injury induces changes in the sodium-potassium pump that disrupt fluid and electrolyte homeostasis, and surgery causes changes in functional extracellular fluid.